Sunday, February 17, 2013

Obama Pitches Universal Preschool Education

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President Obama took up the issue of early education Thursday, unveiling a proposal to provide universal preschool to children in America.

The White House plan calls for the government to partner with states to provide preschool funding for all 4-year-olds from low and moderate-income families.

Obama made the pitch for his plan while visiting a Georgia pre-K program.

Some conservatives are calling this proposal federal overreach. Dr. Carlos Campo, president of Regent University, offers more insight, on CBN Newswatch, Feb. 14.

"Education has to start at the earliest possible age and that's what you've realized here in Decatur," Obama said.

As part of the initiative, the president also wants to expand the Head Start preschool program to include toddlers and infants of underprivileged families.

"Study after study shows that the earlier a child begins learning the better he or she does down the road. But here's the thing: we are not doing enough to give all our kids that chance," he said.

The education proposal doesn't have a price tag yet but the plan would be funded with federal matching dollars for families who earn at or below 200 percent of the poverty line.

States that expand preschool slots for middle-class families will also get extra government money.

But critics of the plan say states or private programs could spend the money and run the preschool programs more efficiently than the federal government.

Meanwhile, Republican lawmakers are uneasy about an expanded federal role in pre-K. The president's plan will require congressional approval.

 

 


 

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Synthetic Marijuana Use Associated With Acute Kidney Injury

Editor's Choice
Main Category: Alcohol / Addiction / Illegal Drugs
Also Included In: Urology / Nephrology
Article Date: 15 Feb 2013 - 10:00 PST Current ratings for:
Synthetic Marijuana Use Associated With Acute Kidney Injury
not yet rated5 stars
Over 16 new cases of people suffering from acute kidney injury after smoking synthetic marijuana have been reported in six states across the U.S.

The report, published by the Centers for Disease Control and Prevention (CDC), identified an association between the use of synthetic cannabinoids (SCs), such as "Spice" and "K2", and kidney damage.

The sixteen patients began to experience symptoms of kidney failure within days of smoking the substance, complaining severe abdominal pains as well as vomiting and nausea.

All of the patients visited emergency departments and were subsequently hospitalized. Most of the them, except one fifteen year old girl, were males aged 15-33 (at average age of 18.5). Fifteen of them suffered from nausea and vomiting and twelve experienced abdominal, back, or flank pain. None of the patients had pre-existing renal dysfunction.

Synthetic marijuana is a designer drug derived from natural herbs which are sprayed with certain chemicals, mildly mimicking the psychoactive effects of the active ingredient in cannabis called THC.

Spice drug
Synthetic marijuana, a "designer drug" derived from herbs and sprayed with chemicals

The health effects of smoking SCs are thought to be riskier than regular cannabis. In fact, last year at the American Psychiatric Association Annual Meeting, researchers revealed findings to suggest that recreational use of synthetic cannabis might lead to psychosis lasting for up to months.

People often smoke synthetic forms of marijuana as it can be cheaper and not appear on drug tests, making it an appealing alternative to regular cannabis.

According to the CDC:

"The expectation of a more intense high than that induced by marijuana, easy access, affordability, and avoidance of detection by many commonly used urine drug tests all contribute to the growing abuse of SCs, especially among male adolescents"

They added:

"Public health practitioners, poison center staff members, and clinicians should be aware of the potential for renal or other unusual toxicities in users of SC products and should ask about SC use in cases of unexplained AKI.

Health-care providers should be aware of renal and other unexpected toxicities from use of SC products, especially with newer SC compounds."

In 2010, a total of 11,406 emergency department visits were associated with synthetic marijuana use, according to the SAMHSA (Substance Abuse and Mental Health Services Administration).

The symptoms linked to SC usage included:

Written by Joseph Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today Visit our alcohol / addiction / illegal drugs section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

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n.p. "Synthetic Marijuana Use Associated With Acute Kidney Injury." Medical News Today. MediLexicon, Intl., 15 Feb. 2013. Web.
16 Feb. 2013. APA

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posted by phil on 16 Feb 2013 at 12:32 am

this article although interesting gave no indication of the type of renal injury that resulted from the drug use. i'm curious as to weather flank/abdo pain was assumed to be renal failure or if there is pathology to back up the claims. did an acute decrease in GFR occur? were electrolyte imbalances seen?

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'Synthetic Marijuana Use Associated With Acute Kidney Injury'

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Saturday, February 16, 2013

The Achilles Tendon Is Not Renewed, Stays The Same Throughout Adult Life

Main Category: Sports Medicine / Fitness
Also Included In: Bones / Orthopedics
Article Date: 15 Feb 2013 - 0:00 PST Current ratings for:
The Achilles Tendon Is Not Renewed, Stays The Same Throughout Adult Life
not yet rated5 stars
Notorious among athletes and trainers as career killers, Achilles tendon injuries are among the most devastating. Now, by carbon testing tissues exposed to nuclear fallout in post WWII tests, scientists have learned why: Like our teeth and the lenses in our eyes, the Achilles tendon is a tissue that does not repair itself. This discovery was published online in The FASEB Journal.

"Tendon injury is a very common disease, which hinders many people from enjoying the numerous benefits of sports and recreational activities," said Katja Heinemeier, Ph.D., a researcher involved in the work from the Institute of Sport Medicine and Center for Healthy Aging at the University of Copenhagen in Denmark. "We hope that these new results will provide the essential knowledge necessary for the development of effective treatments of tendon diseases."

Heinemeier and colleagues made this discovery by taking advantage of carbon-14 spikes resulting from post WWII nuclear bomb tests. Because of these tests, there was there was a large release of the radioactive carbon-14 (radiocarbon) to the atmosphere between 1955 and 1963. This sudden rise in carbon-14 - called the "bomb pulse" - reached a maximum of twice the natural atmospheric level in 1963, and then gradually dropped to the lower levels over time. This variation is reflected in all human tissue, because humans eat plants (and animals fed on plants) that take up carbon-14 from the atmosphere. Researchers studied the Achilles tendons from people who had lived during the carbon-14 bomb pulse peak, and found that the high carbon-14 levels of this period had remained in the tendon tissue for decades after. This persistence of radiocarbon can only be explained by the fact that the rate of tissue renewal is extremely slow in the tendon, if it exists at all. In fact, the results showed that the Achilles tendon stays the same after growing ends. In comparison, muscle tissue from the same persons had been constantly renewed and contained no "memory" of the radiocarbon.

"While the nation waits to see if another Olympic skier or NFL rookie recovers from serious tendon or ligament damage, this report serves as a cautionary tale to temper expectations," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "When it comes to our tendons, what we have may be all we have. Like our teeth, it's far better and less painful in the long term to protect them throughout your lifetime than it is to count on a successful recovery."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our sports medicine / fitness section for the latest news on this subject. Katja Maria Heinemeier, Peter Schjerling, Jan Heinemeier, Stig Peter Magnusson, and Michael Kjaer. Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb 14C. FASEB J doi:10.1096/fj.12-225599; http://www.fasebj.org/content/early/2013/02/11/fj.12-225599.abstract.
The FASEB Journal Federation of American Societies for Experimental Biology Please use one of the following formats to cite this article in your essay, paper or report:

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Pathway That Stimulates Bone Growth Revealed By Veterinary Team

Main Category: Bones / Orthopedics
Also Included In: Stem Cell Research
Article Date: 16 Feb 2013 - 0:00 PST Current ratings for:
Pathway That Stimulates Bone Growth Revealed By Veterinary Team
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Researchers from the University of Pennsylvania School of Veterinary Medicine have discovered that a protein called Jagged-1 stimulates human stem cells to differentiate into bone-producing cells. This protein could help both human and animal patients heal from bone fractures faster and may form the basis of treatments for a rare metabolic condition called Alagille syndrome.

The study, published in the journal Stem Cells, was authored by three members of Penn Vet's departments of Clinical Studies-New Bolton Center and Animal Biology: postdoctoral researchers Fengchang Zhu and Mariya T. Sweetwyne and associate professor Kurt Hankenson, who also holds the Dean W. Richardson Chair in Equine Disease Research.

Last November, on the promise of these and other findings, Hankenson and his former doctoral student Mike Dishowitz launched a company, Skelegen, through Penn's Center for Technology Transfer UPstart program. Skelegen's focus is to continue to develop and improve a system for delivering Jagged-1 to sites that require new bone growth, in the hope of eventually treating bone fractures and other skeletal problems. Penn, through the CTT, has submitted a provisional patent application to protect the inventions of Hankenson and his colleagues.

Although human bones seem static and permanent, bone tissue actually forms and reforms throughout our lives. Cells called osteoblasts form bone and are derived from precursor cells known as mesenchymal stem cells, which are stored in bone marrow. These stem cells must receive specific signals from the body in order to become osteoblasts.

Prior research had identified a molecule called bone morphogenic protein, or BMP, as one of these proteins that drives stem cells to become bone-forming cells. As a result, BMP has been used clinically to help patients healing from broken bones or to perform spinal fusions without relying on patients' own bone tissue.

"But it has become clear that BMPs have some issues with safety and efficacy," Hankenson said. "In the field we're always searching for new ways for progenitor cells to become osteoblasts so we became interested in the Notch signaling pathway."

This molecular signaling pathway is found in most animal species and is known to play a role in stem cell differentiation. The researchers chose to investigate one of the proteins that acts in this pathway by binding to the Notch receptor, Jagged-1. The Penn Vet team has previously shown that Jagged-1 is highly expressed in bone-forming cells during fracture healing and that introducing Jagged-1 to mouse stem cells blocked the progression of stem cells to osteoblasts.

"That had been our operating dogma for a year or two," Hankenson said.

Next the researchers decided to see what happened when Jagged-1 was introduced to human stem cells. There they came upon a very different result.

"It was remarkable to find that just putting the cells onto the Jagged-1 ligand seemed sufficient for driving the formation of bone-producing cells," he said.

This finding aligns with other evidence linking Jagged-1 to bone formation. Patients with a rare disease known as Alagille syndrome frequently have mutations in the gene that codes for Jagged-1. Individuals with this condition have problems with their metabolism that severely affect their livers but also tend to have challenges with their skeletal system and break bones easily.

Furthermore, genome-wide association studies, which search large populations for mutations that may be linked with particular characteristics, have found a connection between mutations near the Jagged-1 gene and low bone mass.

Hankenson has multiple collaborations with other researchers at Penn to further investigate how manipulating the Jagged-1 protein may one day help patients. He is working with Kathleen Loomes of Penn's Perelman School of Medicine and the Children's Hospital of Pennsylvania to study pediatric patients with Alagille syndrome to find out whether their bone abnormalities are indeed connected to Jagged-1 malfunctions.

And in addition to partnering with Dishowitz to develop the technology to deliver Jagged-1 to bone repair sites, Hankenson is also collaborating with Jason Burdick in Penn's School of Engineering and Applied Science and Jaimo Ahn and Samir Mehta of Penn Medicine to improve and implement this system.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our bones / orthopedics section for the latest news on this subject. The U.S. Department of Defense provided support for the research.
University of Pennsylvania Please use one of the following formats to cite this article in your essay, paper or report:

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n.p. "Pathway That Stimulates Bone Growth Revealed By Veterinary Team." Medical News Today. MediLexicon, Intl., 16 Feb. 2013. Web.
16 Feb. 2013. APA

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Friday, February 15, 2013

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